Just 30 seconds of rinsing, twice a day. ​That’s all it takes when you use LISTERINE Antiseptic Mouthwash. Sure, it's a little intense. You’ll get 24-hour protection with Clinically proven health benefits The power to kill germs that lead to bad breath, plaque and gum disease 21% greater gingivitis reduction than merely brushing and flossing alone Was shown in a clinical study to reduce 52% more plaque than brushing and flossing alone Direction Rinse full strength for 30 seconds with 20 ml (2/3 fluid ounce or 4 teaspoonfuls) morning and night. Do not swallow.